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Defects in insulin/IGF-1 signaling stimulate muscle protein loss by suppressing protein synthesis and increasing protein degradation. Since an herbal compound, berberine, lowers blood levels of glucose and lipids, we proposed that it would improve ...
www.ncbi.nlm.nih.gov
"Besides accelerated protein degradation causing muscle atrophy, a decrease in protein synthesis will cause loss of muscle protein. Mechanisms changing protein synthesis include impaired insulin/IGF-1 signaling, reducing PI3K and p-Akt activities"
"Berberine administration decreased protein synthesis and increased degradation in muscles of normal and
db/db mice"
